Rapid and High-Yielding Disulfide Bioconjugation at Any Desired Site in Proteins
The Research group of Dr. Dimpy Kalia, Department of Chemistry developed StapleAld technology enables stable, rapid, and quantitative disulfide bioconjugation of solvent-exposed cystine disulfides in proteins under physiological conditions. This chemistry is rendered location agnostic when used in tandem with the LAP tag technology (LAP-StapleAld) that allows the installation of lipoyl disulfide linkages at any desired site on any protein. This work has been published in the prestigious Journal of the American Chemical Society (JACS). For more details, kindly visit https://pubs.acs.org/doi/full/10.1021/jacs.5c13581
